AS Fortuna was established in 1998 in Mfou, Cameroon. The club's early years were dedicated to building a competitive team and establishing a strong presence in Cameroonian football. While specific achievements during this period are limited, the foundation laid the groundwork for future successes.

In 2018, AS Fortuna achieved promotion to the Elite One Cameroon Championship, marking a significant milestone in the club's history. In their inaugural season in the top tier, they finished 14th, showcasing their potential to compete at higher levels.

Building on their top-tier experience, AS Fortuna demonstrated remarkable improvement in the subsequent seasons:

2019 Season: The club secured a commendable 4th place finish, reflecting their growing competitiveness.

2020–2021 Season: AS Fortuna continued its upward trajectory by finishing in 3rd place, underscoring their status as a formidable force in Cameroonian football.

AS Fortuna is known for its distinctive red and white team colors, which are prominently featured in their home kits. The club's nickname, "Les Lions Indomptables de Mfou," translates to "The Indomitable Lions of Mfou," reflecting the team's fierce and competitive spirit. The Centre sportif académique de Mbankomo, with a capacity of 1,000 spectators, serves as the home ground, fostering a vibrant atmosphere for fans and players alike.